My first play through resulted in the first ending. I killed one of the people mid-way through because he was pretty evil and given the choice, I felt the world would be better without him. Apparently the little Daughter learns from this that she should kill her mom (having judged her mother to be irredeamable).
The first ending in this video is the ending I got my first play through. I accidently harvested a few little sisters rand said “meh” and didn’t reload. You see, if you remap your keyboard so that the Use key isn’t “F”, the indicators for whether you harvest or save don’t update dynamically. It was quite bewildering when I first played through, only to discover that I couldn’t save the little sister because the button combinations didn’t work. (It says “Press F” to save the little sister, and I did and nothing happened.) As I got the hang of it, I still sometimes pressed the wrong buttons (the key mapping wasn’t as easy as I remember Bioshock 1 being… on the other hand, it might just be that I’m getting older and am beginning to suck at 1P shooters.)
I let the first “boss” (the old woman) live, I killed the other guy (his name escapes me), killed “alex the great” as his sane-recordings asked that I do, and I said “Save myself” at the end once I got up to the surface. Voila, ending 1.
Considering my choices, I imagine if I’d said sacrifice I would have received Ending 3. The only thing that caused me to choose “save myself” over “sacrifice” was something she said about if I chose “X” it would indicate I had regret, and if she didn’t know if she could be a monster if I had regret. I must have misunderstood which choice signified regret.

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